Desmoglein 1 and 3 antibodies, IgG-994

Test info

  
Desmoglein 1 and 3 antibodies, IgG
  
994
  
LAB994
  
MSO
  
Desmoglein 1 and 3 IgG
Pemphigus Autoantibodies
  

This test is a preferred screening test for patients suspected to have an autoimmune blistering disorder of the skin or mucous membranes (pemphigus). This test aids in the diagnosis of pemphigus. The antibody levels can be used to monitor the effectiveness of drug treatment.

Specimen

  
Serum
  
  
2.0 mL
  
1.0 mL
Submission of the minimum volume does not allow for repeat testing
  

Immediately following collection, thoroughly mix sample by gently inverting 5 times

  
  1. Allow sample to clot for a minimum of 30 minutes
  2. Spin within two (2) hours of sample collection
  3. Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp)
  4. Freeze
  
  

Frozen (preferred) - 14 days

Ambient - 8 hours

Refrigerated - NO

  • Freeze/thaw cycles - stable x3
  
  • Bacterial contamination
  • Hemolysis or Lipemia

Performance

  
LabCorp (164122): R-NX
  
6 days
  

Enzyme Immunoassay (EIA)

Clinical and Interpretive info

  

See report

  

Pemphigus diseases involve an autoimmune response primarily targeting desmoglein (Dsg) 1 and 3, which are cadherin-type transmembrane adhesion molecules. These desmogleins, in conjunction with desmocollins, play a crucial role in maintaining the cohesion between epidermal keratinocytes and are connected internally to the intermediate filament network through various plakins.

Pemphigus foliaceus (PF) is characterized by IgG autoantibodies against Dsg1, resulting in blistering limited to the upper skin, with no evident involvement of mucous membranes. On the other hand, pemphigus vulgaris (PV) primarily targets Dsg3 as the major autoantigen, but approximately 50% to 60% of patients also develop additional autoantibodies against Dsg1, leading to significant mucous membrane involvement.

Billing

  
83516 x 2
  
Result SOLOINC

Tracking

  
05/30/2019
  
01/30/2024
  
01/30/2024