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Isocitrate dehydrogenase 1 & 2 gene mutation assay-Pathology add-on

Test info

Test name:

Isocitrate dehydrogenase 1 & 2 gene mutation assay

Test number:

Pathology add-on

Alternate names:

R132
R172
IDH1
IDH2
Isocitrate dehydrogenase 1 - soluble
Isocitrate dehydrogenase 2 - mitochondrial

Useful for:

Identification and characterization of tumors in the brain. In addition to diagnostic value, IDH1 and IDH2 mutations have been associated with better outcome and longer survival, especially in conjunction with p53 and 1p19q deletions.

Specimen

Specimen type:

Tissue
Surgical or biopsy tumor specimen

Processing instructions:

Tissues should be processed according to standard FFPE protocols. Over fixing of samples should be avoided as this can cause DNA degradation.

Transport container:

Formalin-fixed, paraffin-embedded (FFPE) tissue block

Transport and stability:

Ambient

Performance

Performing lab:

AHL - Molecular Diagnostics: D

Days set up:

Varies

TAT:

8 days

Method:

Polymerase Chain Reaction (PCR) with Melt Curve analysis

Clinical and Interpretive info

Reference ranges:

An interpretative report will be provided

Billing

Preauthorization:

This test may require preauthorization from the insurance provider. Check the payer guidelines and, if needed, obtain the pre-authorization prior to sample collection.

CPT codes:

81403 - IDH 1
81403 - IDH 2

Tracking

Date created:

10/26/2010

Revised date:

07/27/2018

Review date:

03/13/2020