21-hydroxylase autoantibodies-13424

Test info

  
21-hydroxylase autoantibodies
  
13424
  
LAB13424
  
21H
  
Adrenal 21-hydroxylase autoantibodies
  

Addison's disease (chronic primary adrenal insufficiency) is commonly caused by autoimmune destruction of the adrenal cortex and is characterized by the presence of adrenal cortex autoantibodies in the serum. It can occur sporadically or in combination with other autoimmune endocrine diseases, that together comprise Type I or Type II autoimmune polyglandular syndrome. The microsomal autoantigen, steroid 21-hydroxylase enzyme has been shown to be the primary autoantigen associated with autoimmune Addison disease. Measurement of 21-hydroxylase autoantibodies aids in the diagnosis and management of patients of adrenal insufficiency.

Specimen

  
Serum
  
  
0.5 mL
  
0.2 mL
Submission of the minimum volume does not allow for repeating testing
  

Immediatley following collection, mix sample by gently inverting 5 times

  
  1. Allow sample to clot for a minimum of 30 minutes
  2. Spin within one (1) hours of sample collection

 

  

Gold serum separator (SST) tube

  
  
  1. Allow sample to clot
  2. Spin within one (1) hours of sample collection
  3. Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as serum
  
  

Ambient (preferred) - 14 days

Refrigerated - 14 days

Frozen - 2 years

Freeze/thaw cycles - stable x 6

  
  • Gross hemolysis
  • Gross lipemia

Performance

  
Esoterix Endocrinology (500036) via LabCorp (504805): R-NX
  
We
  
10 days
  

Enzyme-linked Immunosorbent Assay (ELISA)

Clinical and Interpretive info

  

Negative

Billing

  
83516

Tracking

  
01/21/2020
  
12/20/2023
  
12/20/2023