Inflammatory Bowel Disease (IBD)

Alphabetical Test listing

Inflammatory Bowel Disease (IBD)-13541

  
Inflammatory Bowel Disease (IBD)
  
13541
  
LAB13541
  
IBD
  
Bowel disease
Crohn's disease
Ulcerative colitis
  
Atypical perinuclear antineutrophil cytoplasmic antibodies (pANCA); Saccharomyces cerevisiae, IgA; Saccharomyces cerevisiae, IgG
  

Rule out Crohn's disease and ulcerative colitis

  
Serum
  
  
1.5 mL
  
0.7 mL
Submission of the minimum volume does not allow for repeat testing
  

Immediatley following collection, mix sample by gently inverting 5 times

  

1. Allow sample to clot for a minimum of 30 minutes
2. Spin within two (2) hours of sample collection

  

Gold serum separator (SST) tube

 

  
  
  1. Allow sample to clot
  2. Spin within two (2) hours of sample collection
  3. Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as serum
  
  

Refrigerated

  
  • Bacterial contamination
  • Hemolysis
  •  Lipemia
  
LabCorp Burlington (164830): R-LC
  
2 - 5 days
  

Atypical ANCA: Indirect fluorescent antibody (IFA)

Saccharomyces cerevisiae, IgA and IgG: Enzyme immunoassay (EIA)

  

Saccharomyces cerevisiae,IgA                                             

Negative: <20.0
Equivocal:    20.1 - 24.9
Positive:   ≥ 25.0

Saccharomyces cerevisiae, IgG

Negative: <20.0
Equivocal:    20.1 - 24.9
Positive:   ≥ 25.0

Atypical pANCA                     

Negative: < 1:20

  

IgA and IgG antibody testing for S. cerevisiae is useful adjunct testing for differentiating Crohn's disease and ulcerative colitis.  Nearly 80% of Crohn's disease patients are positive for either IgA or IgG.  In ulcerative colitis, less than 15% are positive for IgG, and less than 2% are positive for IgA.  Fewer than 5% of healthy controls are positive for either IgG or IgA antibody, and no healthy controls had antibody for both.  The atypical ANCA pattern has been observed in a significant percentage of patients with ulcerative colitis, primary sclerosing cholangitis, and autoimmune hepatitis.

  
86671 x 2
86037
  
17029308
17029309 x 2
  
308603701
308667104 x 2
  
Result 49503-6
  
04/08/2019
  
12/31/2023
  
12/31/2023