CD68 by IHC

Alphabetical Test listing

CD68 by IHC-12376 - Technical only, 12379 - Technical & interpretation

Test name:

CD68 by IHC

Test number:

12376 - Technical only, 12379 - Technical & interpretation

Excellian order number:

LAB12376
LAB12379

Alternate names:

KP1

Tests included:

All IHC stains will include a positive control tissue

Useful for:

KP1 reacts with cells of monocyte/macrophage or myelomonocytic lineage (this includes epithelial histiocytes, multinucleated histiocytes, osteoclasts, giant cells in giant cell tumors of bone, Gaucher's cells, sea blue histiocytes)
KP1 will also react with neutrophils, mast cells and basophils; and will stain myeloid leukemias (useful in the workup of a chloroma)
KP1 can stain a wide variety of non-Hodgkin's lymphomas of B-cell phenotype (most frequently KP1 positive NHL's are small lymphocytic and diffuse, small cleaved NHL)
KP1 stains granular cell tumors, and Schwann cells in benign peripheral nerve sheath tumors
KP1 is not highly specific; KP1 also may react with hepatocytes, kidney tubules and glomeruli, pancreatic acini and islets, skin epithelium, sweat glands, connective tissue, and endothelial cells
KP1 reactivity has also been reported in MFH, renal cell carcinoma, malignant melanoma, meningioma, glioblastoma, infiltrating duct carcinoma of the breast

Specimen type:

Tissue

Processing instructions:

Submit a formalin-fixed, paraffin embedded tissue block

Transport container:

Formalin-fixed, paraffin embedded (FFPE) tissue block

Alternate transport container:

FFPE tissue section mounted on a charged, unstained slide

Transport and stability:

Ambient (preferred)

Reason for rejection:

Unlabeled/mislabeled block
Insufficient tissue
Slides broken beyond repair

Performing lab:

AHL - Immunohistochemistry

Days set up:

Mo - Fr

TAT:

1 - 2 days

Method:

Immunohistochemical staining and microscopic examination

Reference ranges:

If requested, an interpretive report will be provided

Clinical information:

Specifications

CD68/KP1 is an antibody that recognizes an intracellular glycoprotein associated with lysosomes, phagosomes, and primary granules of neutrophils. It is a very useful marker for identifying macrophages/histiocytes

Staining pattern

Granular cytoplasmic based staining

References

Weiss, et. al.: CD68; A Review; Appl. Immunohistochemistry 2(1):2-8, 1994.
Horny, et. al.: Assessment of the Value of Immunohistochemistry in the Subtyping of Acute Leukemia on Routinely Processed Bone Marrow Biopsy.

CPT codes:

88342 - 1st stain
88341 - each additional stain

Date created:

06/16/2017

Revised date:

10/18/2018

Review date:

01/12/2024