Signal Recognition Particle

Alphabetical Test listing

Signal Recognition Particle-994

  
Signal Recognition Particle
  
994
  
LAB994
  
MSO
  
SRP
Anti-SRP Ab
  

SRP is considered a Myositis-specific antibody. It is commonly found in Polymyositis, ILD and arthritis, and occasionally in dermatomyositis. Anti-SRP was first described in a polymyositis patient in 1986. Anti-SRP antibodies are rare, in only about 4% of myositis patients, and are often found in African American females with an acute, severe onset of polymyositis, with poor response to therapy.

  
Serum
  
  
1.0 mL
  
0.3 mL
(Note: This volume does not allow for repeat testing.)
  

Immediatley following collection, mix sample by gently inverting 5 times

  
  1. Allow sample to clot for a minimum of 30 minutes
  2. Spin within one (1) hour of sample collection
  3. Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as serum
  
  
  1. Allow sample to clot
  2. Spin within one (1) hour of sample collection
  3. Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as serum
  

Refrigerated (preferred) - 14 days

Ambient - 7 days

Frozen - 60 days

  
  • Grossly hemolyzed
  • bacterial contamination
  • lipemic specimen
  • icteric specimen
  
LabCorp (520014): R-NX
  
Weekly
  
14 - 21 days
  

RIPA gel radiography

  

Negative

The presence of SRP antibodies is predominantly associated with polymyositis. The prevalence of SRP antibodies in idiopathic inflammatory myopathy is 4-5%

  
83516
  
05/23/2019
  
02/02/2021
  
08/16/2023