Immunoglobulin G, subclasses (1-4)

Alphabetical Test listing

Immunoglobulin G, subclasses (1-4)-13549

  
Immunoglobulin G, subclasses (1-4)
  
13549
  
LAB13549
  
IGGSUB
  
IgG Subclasses
IgG(1,2,3,4)
  

Study patients with recurrent bacterial infections or allergy.

  
Serum
  
Serum - Red
  

Gold SST

  
3.0 mL
  
1.8 mL
  

Spin, separate and freeze

  

LabCorp screw-capped purple frozen plastic transport tube

  

Frozen (preferred)  - 13 days

Refrigerated  - 7 days

Ambient - 3 days

  
  • Gross lipemia
  • Hemolysis
  
LabCorp Burlington (209601): R-LC
  
Daily
  
2 - 4 days
  

Immunologic

  

Immunoglobulin G, quant (mg/dL)

Age

Male

Female

0 - 10 days

11 days - 6 months

7 - 11 months

1 - 3 years

4 - 6 years

7 - 9 years

10 -11 years

12 - 13 years

14 - 15 years

16 - 19 years

>19 years

496 - 1231

175 - 639

261 - 791

428 - 1028

538 - 1216

580 - 1302

601 - 1351

610 - 1367

630 - 1392

671 - 1456

603 - 1613

496 - 1231

184 - 697

295 - 787

451 - 1071

583 - 1262

630 - 1350

646 - 1407

692 - 1433

717 - 1463

719 - 1475

586 - 1602

IgG subclasses

Subclass 1: 248 - 810 mg/dL

Subclass 2: 130 - 555 mg/dL

Subclass 3:   15 - 102 mg/dL

Subclass 4:     2 - 96     mg/dL

  

There are four subtypes, of which IgG(1) and IgG(2) comprise 85% of the total. IgG(1) and IgG(3) fix complement best; IgG(3) is hyperaggregable and effects serum viscosity disproportionately.
IgG antibody responses to certain antigens occur to a greater extent in one type of IgG subclass than another. Therefore, some patients with normal total IgG levels may have problems with pyogenic infections because they do not produce IgG(2) or combinations of IgG(2), IgG(3), and/or IgG(4). Some clinically significant IgG subclass deficiencies occur in patients who have IgA deficiency.
The four subclasses of IgG differ in the constant regions of their heavy chains. A patient may have a normal totalIgG yet still have a significant decrease in one subclass. IgG(1) deficiencies are associated with EBV infections, IgG(2) with sinorespiratory infections and infections with encapsulated bacteria, IgG(3) with sinusitis and otitis media, and IgG(4) with allergies, ataxia telangiectasia, and sinorespiratory infections. See tables in individual subclass listings.

  
82784
82787 x 4
  
Result 2465-3
  
04/08/2019
  
03/30/2020