INSM1-NE by IHC

Alphabetical Test listing

INSM1-NE by IHC-12376 - Technical only; 12379 - Technical & Interpretation

  
INSM1-NE by IHC
  
12376 - Technical only
12379 - Technical & Interpretation
  
LAB12376
LAB12379
  
Insulinoma-associated 1
  
  • INSM1 is positive in neuroendocrine tumors and in normal adult neuroendocrine tissues and developing neurons.
  • INSM1 positivity has been described in the following neoplasms:
    • CNS tumors: Pituitary adenoma, central neurocytoma, medulloblastoma, glioblastoma, pineal parenchymal tumor
    • Endocrine: Adrenal pheochromocytoma, paraganglioma, medullary carcinoma of the thyroid, and neuroblastoma
    • Gastrointestinal tract: Pancreatic neuroendocrine tumors (100%) and gastrointestinal neuroendocrine tumors (100%)
    • Lung: Small cell carcinoma (95%), large cell neuroendocrine carcinoma (90%), typical and atypical carcinoid (100%). Weak or focal positivity has been reported in lung adenocarcinomas (3%) and squamous cell carcinomas (4%).
    • Skin: Merkel cell carcinoma (93%), endocrine mucin producing sweat gland carcinoma
    • Soft tissue tumors: Extraskeletal myxoid chondrosarcoma (90%), chordoma (10%), soft tissue myoepithelioma (5%), ossifying fibromyxoid tumor (30%), and Ewings sarcoma (30%)
  • INSM1 positivity has been reported in the following in tumors with neuroendocrine differentiation: Breast adenocarcinoma, colonic adenocarcinoma, endometrioid carcinoma, and prostate adenocarcinoma
  • INSM1 is positive in the following normal tissues: Adrenal medulla, enterochromaffin cells, islet cells, C cells of the thyroid, pineal gland, pituitary gland, and in neurons in early development

References:

1. Ames HM et al. INSM1 expression is frequent in primary central nervous system neoplasms but not in the adult brain parenchyma. J Neuropathol Exp Neurol 2018;77(5):374-382.

2. Fujino K et al. INSM1 is the best marker for the diagnosis of neuroendocrine tumors: comparison with CGA, SYP and CD56. Int J Clin Exp Pathol 2017;10(5):5393-5405.

3. Lilo MT et al. INSM1 is more sensitive and interpretable than conventional immunohistochemical stains used to diagnose merkel cell carcinoma. Am J Surg Pathol 2018;42(11):1541-1548.

4. Rosenbaum JN et al. A novel immunohistochemical and molecular marker for neuroendocrine and neuroepithelial neoplasms. Am J Clin Pathol 2015;144:579-591.

5. Rooper LM et al. INSM1 demonstrates superior performance to individual and combined use of synaptophysin, chromogranin and CD56 for diagnosing neuroendocrine tumors of the thoracic cavity. Am J Surg Pathol 2017;41(11):1561-1569.

6. Yoshinda et al. INSM1 expression and its diagnostic significance in extraskeletal myxoid chondrosarcoma. Mod Pathol 2018;31:744-752.

  
Tissue
  

Submit processed tissue block

  

Formalin-fixed, paraffin embedded (FFPE) tissue block.

  

Ambient (preferred)

  
AHL - Immunohistochemistry
  
Mo - Fr
  
1 - 2 days
  

Immunohistochemical staining

Microscopic examination

  

If requested, an interpretive report will be provided

  

All IHC stains will include a positive control tissue on each slide.

Specifications:

Zinc finger transcription factor involved in development of normal neuroendocrine cells throughout the body and involved in tumor neuroendocrine differentiation. 


Staining pattern:

  • Nuclear
  
88342 - 1st stain
88341 - each additional stain
  
03/04/2019
  
06/25/2019