1. Ames HM et al. INSM1 expression is frequent in primary central nervous system neoplasms but not in the adult brain parenchyma. J Neuropathol Exp Neurol 2018;77(5):374-382.
2. Fujino K et al. INSM1 is the best marker for the diagnosis of neuroendocrine tumors: comparison with CGA, SYP and CD56. Int J Clin Exp Pathol 2017;10(5):5393-5405.
3. Lilo MT et al. INSM1 is more sensitive and interpretable than conventional immunohistochemical stains used to diagnose merkel cell carcinoma. Am J Surg Pathol 2018;42(11):1541-1548.
4. Rosenbaum JN et al. A novel immunohistochemical and molecular marker for neuroendocrine and neuroepithelial neoplasms. Am J Clin Pathol 2015;144:579-591.
5. Rooper LM et al. INSM1 demonstrates superior performance to individual and combined use of synaptophysin, chromogranin and CD56 for diagnosing neuroendocrine tumors of the thoracic cavity. Am J Surg Pathol 2017;41(11):1561-1569.
6. Yoshinda et al. INSM1 expression and its diagnostic significance in extraskeletal myxoid chondrosarcoma. Mod Pathol 2018;31:744-752.
Submit processed tissue block
Formalin-fixed, paraffin embedded (FFPE) tissue block.
If requested, an interpretive report will be provided
All IHC stains will include a positive control tissue on each slide.
Zinc finger transcription factor involved in development of normal neuroendocrine cells throughout the body and involved in tumor neuroendocrine differentiation.