IgG4 by IHC

Alphabetical Test listing

IgG4 by IHC-12376 - Technical only; 12379 - Technical & Interpretation

IgG4 by IHC
12376 - Technical only
12379 - Technical & Interpretation
  • Elevated serum IgG4 levels may be associated with localized or systemic allergic and autoimmune manifestations, such as inflammatory pseudotumor in liver, breast, and lung, sclerosing pancreatitis, and pemphigus vulgaris
  • In these disease states, increased numbers of IgG4-positive plasma cells are present in the tissue



Submit processed tissue block or tissue section mounted on a charged, unstained slide


Formalin-fixed, paraffin embedded (FFPE) tissue block


Ambient (preferred)

AHL - Immunohistochemistry
Mo - Fr
1 - 2 days

Immunohistochemical staining

Microscopic examination


If requested, an interpretive report will be provided


All IHC stains will include a positive control tissue


  • Immunoglobulin function as the surface receptors for antigens for B lymphocytes and as the secretory products of plasma cells forming the humoral arm of the immune system.
  • IgG represents one of the immunoglobulin heavy chain types
  • IgG4 is the least abundant of IgG subclasses, normally comprising 6% of total IgG

 Staining pattern:

  • Cytoplasmic
88342 - 1 st stain
88341 - each additional stain