This assay has been discontinued. The referred alternate is an order placed for a MSO 994/LAB994 for 512275: DPYD Genotyping | Labcorp
Variability in response (efficacy and toxicity) to 5-fluorouracil (5-FU) chemotherapy has been linked to the rate-limiting enzyme in the drug's catabolic pathway, known as dihydropyrimidine dehydrogenase (DPD)
This procedure will only detect the presence of the wild type or mutant allele for the DPD IVS14+1G>A mutation
Immediately after collection, mix tube thoroughly by gentle inversion, 8 - 10 times, to prevent clotting
Lavender (EDTA), 10mL
Yellow ACD (A or B)
Immediately following collection, mix by inverting 8 - 10 times to prevent clotting
Yellow ACD (A or B)
Molecular Medicare billing request
Ambient (preferred)
Refrigerated
Polymerase chain reaction (PCR), restriction enzyme digestion and gel electrophoresis
An interpretive report will be provided
Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medical billing request form along with the sample.