Lt green plasma separator (PST)
Gold serum separator (SST) tube
Refrigerated (preferred) - 7 days
Frozen - 6 months
|1 - 14 years||188-388 mg/dL||180-391 mg/dL|
|>14 to 60 years||174 - 364 mg/dL||180 - 382 mg/dL|
|>60 to 80 years||166 -344 mg/dL||173 - 360 mg/dL|
Transferrin is a β-globulin, synthesized primarily in the liver, which is the principal protein responsible for iron transport. Transferrin transports ferric ions from the iron stores of intracellular or mucosal ferritin to bone marrow where erythrocyte precursors and other cells have transferrin surface receptors. Transferrin is responsible for 50% to 70% of the iron binding capacity of serum. Since other proteins may bind iron, transferrin concentration correlates with, but is not identical to, Total Iron Binding Capacity (TIBC).
Iron deficiency and iron overload are best diagnosed using a combination of iron, transferrin, and ferritin determinations.
Decreased levels of transferrin are also associated with conditions involving chronic liver disease, malnutrition, nephrotic syndrome, protein-losing enteropathies, iron overload due to multiple transfusion or hereditary hemochromatosis, and congenital atransferrinemia.
Elevated levels of transferrin are associated with iron deficiency anemia where elevated transferrin often precedes the appearance of anemia by days to months. Transferrin levels are also elevated with increased estrogen due to pregnancy, oral contraceptives, etc.