Transferrin

Alphabetical Test listing

Transferrin-121

  
Transferrin
  
121
  
84466.0
  
TRF
  
  • Screening for nutritional status
  • Differential diagnosis of anemia
  • Monitoring anemia treatment

 

  
Lithium heparin (Li hep) plasma
  
  
1.0 mL
  
0.25 mL
  

Spin

  

Lt green plasma separator (PST)

  
Serum
  
  

Spin

  

Gold serum separator (SST) tube

  

Refrigerated (preferred) - 7 days

Frozen - 6 months

  
AHL - Chemistry: C
  
Daily
  
1 - 2 days
  

Immunoturbidimetric

  
Age Male Female
1 - 14 years 188-388 mg/dL 180-391 mg/dL
>14 to 60 years 174 - 364 mg/dL 180 - 382 mg/dL
>60 to 80 years 166 -344 mg/dL 173 - 360 mg/dL
  

Transferrin is a β-globulin, synthesized primarily in the liver, which is the principal protein responsible for iron transport. Transferrin transports ferric ions from the iron stores of intracellular or mucosal ferritin to bone marrow where erythrocyte precursors and other cells have transferrin surface receptors. Transferrin is responsible for 50% to 70% of the iron binding capacity of serum. Since other proteins may bind iron, transferrin concentration correlates with, but is not identical to, Total Iron Binding Capacity (TIBC).

Iron deficiency and iron overload are best diagnosed using a combination of iron, transferrin, and ferritin determinations.

Decreased levels of transferrin are also associated with conditions involving chronic liver disease, malnutrition, nephrotic syndrome, protein-losing enteropathies, iron overload due to multiple transfusion or hereditary hemochromatosis, and congenital atransferrinemia.

Elevated levels of transferrin are associated with iron deficiency anemia where elevated transferrin often precedes the appearance of anemia by days to months. Transferrin levels are also elevated with increased estrogen due to pregnancy, oral contraceptives, etc.

  
84466
  
Yes
  
  
11/30/2001
  
06/02/2020
  
06/02/2020