T-Pit is used in conjunction with SF-1 and Pit-1 immunohistochemical stains to classify pituitary adenomas. The presence of T-Pit nuclear reactivity within a monomorphous population of neuroendocrine cells within the sella turcica strongly supports adrenocorticotropin lineage. T-Pit is considered to be more sensitive and specific than ACTH IHC6.
Submit a formalin-fixed, paraffin embedded tissue block
Formalin-fixed, paraffin embedded (FFPE) tissue block
FFPE tissue section mounted on a charged, unstained slide
Immunohistochemical staining and microscopic examination
If requested, an interpretive report will be provided
T-Pit (T-box family member TBX19) regulates the proopiomelanocortin (POMC) lineage giving origin to corticotrophs