Microsatellite instability

Alphabetical Test listing

Microsatellite instability-Pathology add-on

Test name:

Test number:

Pathology add-on

Alternate names:

MSI

Useful for:

Analysis of MSI at 5 gene loci.

MSI PCR is often performed in conjunction with analysis of DNA mismatch repair enzymes by immunohistochemistry. Deficient DNA repair and MSI are associated with Lynch Syndrome, and may also be used to determine eligibility for drug therapy

Specimen type:

Tumor tissue

Collection instructions:

Along with the tumor specimen, a normal control from the patient must be submitted.

The preferred normal control is a negative tissue block. If none is available, 5.0 mL of whole blood (ACD, EDTA or NaCitrate) may be submitted.

Transport container:

Formalin-fixed, paraffin-embedded (FFPE) tissue block

Required forms/information:

Molecular Medicare billing request

Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medical billing request form along with the sample.

Complete and submit the form to notify us of the need for Allina Health Laboratory to bill insurance for Molecular testing performed
All information requested is required in order for your request to be completed

Transport and stability:

Ambient

Reason for rejection:

Improper label (unlabeled or mislabeled)
Improper storage
Interfering substances
Slides broken beyond repair

Performing lab:

AHL - Molecular Diagnostics: D

Days set up:

Weekly

TAT:

7 days

Method:

Multi-plex Polymerase Chain Reaction (PCR) analyzed by capillary electrophoresis

Reference ranges:

An interpretative report will be included

Preauthorization:

This test may require preauthorization from the insurance provider. Check the payer guidelines and, if needed, obtain the pre-authorization prior to sample collection.

CPT codes:

81301

Subject to medical necessity (Y/N):

Yes

Other billing information:

Medical necessity

Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medical billing request form along with the sample.

Complete and submit the form to notify us of the need for Allina Health Laboratory to bill insurance for Molecular testing performed
All information requested is required in order for your request to be completed

Molecular Medicare billing request

Date created:

10/08/2009

Revised date:

07/11/2023

Review date:

05/06/2022