IgA by IHC

Alphabetical Test listing

IgA by IHC-12376 - Technical only; 12379 - Technical & Interpretation

  
IgA by IHC
  
12376 - Technical only
12379 - Technical & Interpretation
  
LAB12376
LAB12379
  
Immunoglobulin A
  
  • IgA labels plasma cells and related lymphoid cells containing IgA
  • IgA stains will show an interstitial dendritic pattern within lymphoid follicles, (this represents extracellular immune complexes which are bound to the surface of specialized follicular dendritic cells)
  • IgA will label occasional B cell lymphomas

References:

  1. Taylor CR et al: The demonstration of plasma cells and other immunoglobulin-containing cells in formalin-fixed, paraffin-embedded tissues using peroxidase-labelled antibody. J Clin Pathol 1974; 27:14-20.
  2. Taylor CR et al: The immunohistological detection of intracellular immunoglobulin in formalin-paraffin sections from multiple myeloma and related conditions using the immunoperoxidase technique. Clin exp Immunol 1974; 8:417-29.
  
Tissue
  

Submit processed tissue block or tissue section mounted on a charged, unstained slide

  

Formalin-fixed, paraffin embedded (FFPE) tissue block

  

Ambient (preferred)

  
AHL - Immunohistochemistry
  
Mo - Fr
  
1 - 2 days
  

Immunohistochemical staining

Microscopic examination

  

If requested, an interpretive report will be provided

  

All IHC stains will include a positive control tissue

Specifications:

  • This antibody reacts with heavy chains (alpha) of human IgA (Fc-part)
  • This antibody labels plasma cells and various lymphocytes

Staining pattern:

  • Cytoplasmic (plasma cells) and cell surface membrane (lymphocytes)
  
88342 - 1st stain
88341 - each additional stain
  
07/03/2017
  
10/19/2018