Therapeutic drug management
Trough levels are most reproducible
Dk green heparin (Li or Na), no gel
Immediately following collection, mix sample thoroughly by gently inverting 8 - 10 times, to prevent clotting
Refrigerated (preferred)
Ambient - 3 days
Frozen (OK)
High Performance Liquid Chromatography with Ultraviolet Detection; (HPLC-UV)
Mephenytoin: 1.0 - 5.0 µg/mL
Normephenytoin (Nirvanol): 15.0 - 35.0 µg/mL
Mephenytoin
High: 20 µg/mL
Normephenytoin (Nirvanol)
High: 50.0 µg/mL