Pemphigus/Pemphigoid profile I

Alphabetical Test listing

Pemphigus/Pemphigoid profile I-994

  
Pemphigus/Pemphigoid profile I
  
994
  
LAB994
  
MSO
  
Cutaneous Immunofluorescence
  

The detection of anti-skin (IC and BMZ) antibodies aids in the diagnosis, and sometimes prognosis, of chronic vesicular-bullous diseases including pemphigus, pemphigoid, cicatricial pemphigoid, and epidermolysis bullosa acquisita (EBA).

  
Serum
  
  
2.0 mL
  
0.5 mL
  

Immediately following collection, thoroughly mix sample by gently inverting 5 times

  
  1. Allow sample to clot for a minimum of 30 minutes
  2. Spin within two (2) hours of sample collection
  3. Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp)
  
  
  1. Allow sample to clot
  2. Spin 
  3. Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp)
  

Ambient (preferred) - 5 days

Refrigerated - 5 days

Frozen  - 1 year

 

 

  
  • Grossly hemolysis
  • Lipemia
  • Icteric specimens
  • Bacterial contamination
  • Non-serum specimen types
  
Beutner Labs via LabCorp (831739): R-NX
  
Mo - Fr
  
7 days
  

Indirect immunofluorescence (IIF)

  

An interpretive report will be provided

  

Epithelial intercellular antibodies are diagnostic for pemphigus and occur in over 90% of patients with active forms. Because of the species specificity of intercellular antibodies, the use of the dual substrates further distinguishes the intercellular antibodies of pemphigus vulgaris and vegetans from the antibodies of pemphigus foliaceus and erythematosus. Antibodies to basement membrane antigens of stratified squamous epithelium occur in about 70% of active bullous pemphigoid, 50% of vesicular pemphigoid and EBA and 10% of cicatricial pemphigoid patients.

  
88346 x 2
88350
  
05/24/2019
  
07/11/2022
  
07/11/2022