Thyrotropin receptor antibody, serum

Alphabetical Test listing

Thyrotropin receptor antibody, serum-13346

  
Thyrotropin receptor antibody, serum
  
13346
  
LAB13346
  
TRAB
  
LATS
Long-acting thyroid stimulator
TBII
Thyrotropin-binding inhibitory immunoglobulin
TRAb
TSH Receptor Ab
TSH receptor binding inhibitory immunoglob
  

Diagnosis of hyperthyroidism and Graves' disease.

Thyrotropin-receptor antibody is an autoantibody to the thyroid cell receptor for thyroid-stimulating hormone. It can be demonstrated in 90% of patients with Graves' disease, and is the cause of the hyperthyroidism of that condition. The characterization of TRA resolved much confusion about long-acting thyroid stimulator (LATS) and LATS protector, which are both, in fact, thyroid-stimulating autoantibodies which simply behaved differently in animal test systems. These antibodies are present in 50% of euthyroid Graves' disease as well as hyperthyroid patients. They play a major role in the pathogenesis of Graves' disease. Detection of these antibodies is useful in prediction of neonatalhyperthyroidism and prediction of relapse of hyperthyroidism.

  

This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R).

It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.

  
Serum
  
  
0.8 mL
  
0.3 mL
Note: This volume does not allow for repeat testing
  

Spin

  

Gold serum separator (SST) tube

  
  

Spin and separate

  
  

Refrigerated (preferred) - 3 days
Frozen - 1 month
   Freeze/thaw cycles: x1

 

  
  • Citrate plasma specimen
  • Samples collected in heparin or from patients on heparin therapy
  • Lipemic samples
  • Hemolyzed samples
  • Improper labeling
  
LabCorp Burlington (010314): R-LC
  
Daily
  
1 - 2 days
  

Electrochemiluminescence Immunoassay (ECLIA)

  

0.0 - 1.75 units/L

  
Biotin interference - see Patient preparation
  
83520
  
No
  
Result 5385-0
  
04/11/2019
  
11/11/2019