RNA Polymerase III IgG Abs

Alphabetical Test listing

RNA Polymerase III IgG Abs-13643

  
RNA Polymerase III IgG Abs
  
13643
  
LAB13643
  
RNAPOLYMIGG
  

Autoantibodies to RNA Polymerase III antigen are found in 11% to 23% of patients with systemic sclerosis. Patients who are positive for RNA Polymerase III antibodies do not have any of the other antibodies typically found in systemic sclerosis patients such as centromere, Scl-70, or Pm/Scl antibodies. Thus, they are a separate serologic group. Numerous studies have shown that these patients have an increased risk of the diffuse cutaneous form of scleroderma, with high likelihood of skin involvement and hypertensive renal disease. Antibodies to several different types of RNA Polymerases are found in patients with systemic sclerosis. The recombinant immunodominant epitope of RNA Polymerase III can be used in ELISA with high specificity to detect RNA Polymerase III antibodies in patients with the diffuse cutaneous form of systemic sclerosis

  
Serum
  

Gold SST

  
1.0 mL
  
0.5 mL
  

Spin

  

Serum separator (SST) tube

  

Frozen (preferred)- 1 year

Refrigerated - 5 days

Ambient - 48 hours

 

  

Grossly hemolyzed, lipemic, or icteric specimens

  
IMMCO Diagnostic Inc (063) via LabCorp (806381): R-LC
  
1x / week
  
7 - 14 days
  

Enzyme-linked Immunosorbent Assay (ELISA)

  

Negative: < 20

  
83520
  
Result 63329-7
  
11/08/2019
  
04/30/2019