BTK Inhibitor Acquired Resistance Panel

Alphabetical Test listing

BTK Inhibitor Acquired Resistance Panel-994

Test name:

Test number:

994

Excellian order number:

LAB994

Abbreviation:

MSO

Alternate names:

BTK
BTK acquired resistance

Useful for:

This panel detects mutations in BTK and PLC-gamma-2 which are associated with acquired ibrutinib resistance in certain B-cell neoplasms. This panel is appropriate for patients with B-cell neoplasms who have relapsed and/or show acquired (secondary) resistance after an initial response to BTK (Bruton tyrosine kinase) inhibitors.

Specimen type:

Whole blood

Collection container:

Lavender (EDTA), 4mL

Volume:

5 mL

Minimum volume:

3 mL

Collection instructions:

Immediately following collection, mix sample thoroughly by gentle inverting 8 - 10 times, to prevent clotting

Transport container:

Lavender (EDTA), 4mL

Alternate specimen type:

Bone marrow

Alternate specimen volume:

2 mL (min vol 0.5 mL)

Transport and stability:

Refrigerated - 72 hours

Reason for rejection:

Clotted specimens
Frozen specimens

Performing lab:

NeoGenomics; R-NX

TAT:

10 days

Method:

Molecular

CPT codes:

81233; 81320
81479

Date created:

03/21/2024

Revised date:

03/26/2024

Review date:

03/21/2024