Test name:  

Dementia, Autoimmune/Paraneoplastic Evaluation, Serum

Test number:  

12688

Excellian order number:  

LAB12688

Abbreviation:  

DMS1

Alternate names:  

Cognitive decline
Cognitive impairment
DEMES
Dipeptidyl aminopeptidase-like protein 6
Leucine-Rich Glioma Inactivated Protein-1 IgG

Tests included:  

Dementia, Interpretation, S
AMPA-R Ab CBA, S
Amphiphysin Ab, S
Anti-Glial Nuclear Ab, Type 1
Anti-Neuronal Nuclear Ab, Type 1
Anti-Neuronal Nuclear Ab, Type 2
Anti-Neuronal Nuclear Ab, Type 3
CASPR2-IgG CBA, S
CRMP-5-IgG, S
DPPX Ab IFA, S
GABA-B-R Ab CBA, S
GAD65 Ab Assay, S
GFAP IFA, S
IgLON5 IFA, S
LGI1-IgG CBA, S
mGluR1 Ab IFA, S
Neurochondrin IFA, S
NIF IFA, S
NMDA-R Ab CBA, S
Purkinje Cell Cytoplasmic Ab Type 2
Purkinje Cell Cytoplasmic Ab Type Tr

For reflex tests see algorithm on Clinical and Interpretive info tab

Useful for:  

 

Useful for investigating new onset dementia and cognitive impairment plus 1 or more of the following:

• Rapid onset and progression
• Fluctuating course
• Psychiatric accompaniments (psychosis, hallucinations)
• Movement disorder (myoclonus, tremor, dyskinesias)
• Headache
• Autoimmune stigmata (personal history or family history or signs of diabetes mellitus, thyroid disorder, vitiligo, poliosis [premature graying], myasthenia gravis, rheumatoid arthritis, systemic lupus erythematosus)
• Smoking history (20+ pack years) or other cancer risk factors
• History of cancer
• Inflammatory cerebral spinal fluid
• Neuroimaging findings atypical for degenerative etiology