Tyrosinase by IHC

Alphabetical Test listing

Tyrosinase by IHC-12376 - Technical only;12379 - Technical & interpretation

Tyrosinase by IHC
12376 - Technical only
12379 - Technical & interpretation
  • All IHC stains will include a positive control tissue
  • Highly specific marker for identifying melanoma
  • Tyrosinase will not cross react with melanophages, which may obscure the identification of dermal melanocytic cells
  • This marker is 100% specific and >80% sensitive for non-spindle cell type melanomas<
  • Tyrosinase is 100% specific and 85% sensitive for amelanotic melanomas
  • This marker can help identify cellular blue nevi that may be S100 negative
  • Tyrosinase is a very specific marker for identifying malignant melanoma in sentinel lymph nodes

Submit a formalin-fixed, paraffin embedded tissue block


Formalin-fixed, paraffin embedded (FFPE) tissue block


FFPE tissue section mounted on a charged, unstained slide


Ambient (preferred)

AHL - Immunohistochemistry
Mo - Fr
1 - 2 days

Immunohistochemical staining and microscopic examination


If requested, an interpretive report will be provided



  • Tyrosinase is an enzyme, that catalyzes the reaction that forms melanin
  • This antigen is a highly specific marker for melanocytic differentiation, and is only present in melanin producing cells

Staining pattern

  • Cytoplasmic granular staining (a red chromogen is used)


  1. Kaufmann O et al: Tyrosinase, melan-A, and KBA62 as markers for the immunohistochemical identification of metastatic amelanotic melanomas on paraffin sections. Mod Pathol 1998; 11:740-746.
  2. Orchard GE. Comparison of immunohistochemical labeling of melanocyte differentiation antibodies melan-A, tyrosinase, and HMB-45 with NK1/C3 and S100 protein in the evaluation of benign nevi and malignant melanoma. Histochem J 2000:32:475-481.
88342 - 1st stain
88341 - each additional stain