IA-2 autoantibodies

Alphabetical Test listing

IA-2 autoantibodies-13401

  
IA-2 autoantibodies
  
13401
  
LAB13401
  
IA2
  
IA(2) antibodies
ICA(512) autoantibodies
Islet
Tyrosine phosphatase autoantibodies
  
Serum
  
Red
  

Gold SST

  
1.0 mL
  
0.5 mL
Note: This volume does not allow for repeat testing
  

Spin, separate serum to a LabCorp screw-capped purple frozen plastic transport tubeand freeze immediately. Maintain FROZEN until tested.

To avoid delays in turnaround time when requesting multiple tests on frozen samples, submit a separate frozen aliquot for each test requested.

  

LabCorp screw-capped purple frozen plastic transport tube

  

Frozen (preferred) - 107 days

Refrigerated - 3 days

Ambient - 3 days

  

Radioactive isotopes administered 24 hours prior to specimen collection.

  
Esoterix Endocrinology (500255) via LabCorp (141531): R-LC
  
We
  
2 - 8 days
  

Enzyme-linked immunosorbent assay (ELISA)

  

Negative < 7.5
Positive ≥ 7.5

  

Type 1 diabetes, commonly referred to as insulin-dependent diabetes (IDDM), is caused by pancreatic beta-cell destruction that leads to an absolute insulin deficiency. The clinical onset of diabetes does not occur until 80% to 90% of these cells have been destroyed. Prior to clinical onset, type 1 diabetes is often characterized by circulating autoantibodies against a variety of islet cell antigens, including glutamic acid decarboxylase (GAD), tyrosine phosphatase (IA(2)), and insulin. The autoimmune destruction of the insulin-producing pancreatic beta cells is thought to be the primary cause of type 1 diabetes. The presence of these autoantibodies provides early evidence of autoimmunedisease activity, and their measurement can be useful in assisting the physician with the prediction, diagnosis, and management of patients with diabetes. Autoantibodies to IA(2), a tyrosine phosphatase-like protein, are found in 50% to 75% of type 1 diabetics at and prior to disease onset. These autoantibodies are generally more prevalent in younger onset patients. Because the risk of diabetes is increased with the presence of each additional autoantibody, the positive predictive value of the IA(2) antibody test is enhanced when measured in conjunction with antibodies to GAD and insulin.

  
86341
  
Result 31209-0
  
04/08/2019
  
11/15/2019