Trisomy 12 is a recurring abnormality of Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic lymphoma (SLL). According to current NCCN CLL guidelines, trisomy 12 is classified as an intermediate cytogenetic risk factor. 

This test can be ordered individually or as part of a CLL Full Panel or CLL Prognostic Panel (See the individual panel tests for more details).

Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube

- or -

1. Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep), no gel
2. Immediatley following collection, mix sample thoroughly by gently inverting 8 - 10, times to prevent clotting

Transfer aspirate from syringe to transport container.

Submit entire specimen unspun.

Sterile vial/tube 

Dk green Sodium heparin (Na hep), no gel

Core: 

Submit in sterile tube/cup filled with sterile culture medium, sterile Hanks Balance Salt Solution (HBSS) or sterile saline

Whole blood:

Dk green Sodium heparin (Na hep), no gel

Immediately following collection, mix sample thoroughly by gently inverting 8 - 10, times to prevent clotting.

Submit entire specimen unspun

Bone marrow core:

Sterile vial/tube

Whole Blood:

Dk green Sodium heparin (Na hep), no gel

AHL Cytogenetics oncology request

Ambient

• Improper label (unlabeled or mislabeled)
• Wrong container (anticoagulant or solution)
• Delay in transport
• Improper storage
• Leaking container
• Slides broken beyond repair

Fluorescence in situ hybridization (FISH)

Normal or Abnormal with interpretation.

Medical necessity