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BRAF V600 mutation analysis-12365

Test info

Test name:

BRAF V600 mutation analysis

Test number:

12365

Excellian order number:

LAB12365

Abbreviation:

BRAF

Alternate names:

v-raf murine sarcoma viral oncogene homolog B1

Useful for:

Identification of melanoma patients eligible for Vemurafenib treatment
Diagnostic, prognostic and possible therapeutic information for other types of tumors such as lung, colon, thyroid and brain

Specimen

Specimen type:

Tumor specimen

Processing instructions:

Specimen should be formalin-fixed prior to embedding in paraffin.

Transport container:

Formalin-fixed, paraffin embedded (FFPE) tissue block

Required forms/information:

Molecular Medicare billing request

Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medicare billing request form to notify us of the need for Allina Health Laboratory to bill insurance.

Transport and stability:

Ambient

Reason for rejection:

Samples fixed by means other than formalin fixation, such as B+, will not be accepted.
Decalcified bone specimens will not be accepted as this process degrades DNA.

Performance

Performing lab:

AHL - Molecular Diagnostics: D

Days set up:

Varies (weekly)

TAT:

5 - 7 days

Method:

Cobas 4800 BRAF V600 Mutation Test (IVD, Roche)

Clinical and Interpretive info

Reference ranges:

An interpretative report will be included

Clinical information:

Detection of a point mutation most commonly resulting in a V to E change at codon 600.

Billing

Preauthorization:

This test may require preauthorization from the insurance provider. Check the payer guidelines and, if needed, obtain the pre-authorization prior to sample collection.

CPT codes:

81210

Subject to medical necessity (Y/N):

Yes

Other billing information:

Medical necessity

Molecular Medicare billing request

Tracking

Date created:

08/08/2012

Revised date:

05/15/2024

Review date:

01/15/2024