SRP is considered a Myositis-specific antibody. It is commonly found in Polymyositis, ILD and arthritis, and occasionally in dermatomyositis. Anti-SRP was first described in a polymyositis patient in 1986. Anti-SRP antibodies are rare, in only about 4% of myositis patients, and are often found in African American females with an acute, severe onset of polymyositis, with poor response to therapy.

Gold serum separator (SST) tube

Immediatley following collection, mix sample by gently inverting 5 times

1. Allow sample to clot for a minimum of 30 minutes
2. Spin within one (1) hour of sample collection
3. Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as serum

Transfer vial/tube with cap - 12mL (LabCorp)

Red serum vial/tube - 5 mL

1. Allow sample to clot
2. Spin within one (1) hour of sample collection
3. Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as serum

Refrigerated (preferred) - 14 days

Ambient - 7 days

Frozen - 60 days

• Grossly hemolyzed
• bacterial contamination
• lipemic specimen
• icteric specimen

RIPA gel radiography

Negative

The presence of SRP antibodies is predominantly associated with polymyositis. The prevalence of SRP antibodies in idiopathic inflammatory myopathy is 4-5%