Dementia, Autoimmune/Paraneoplastic Evaluation, Spinal Fluid-12687

Test info

  
Dementia, Autoimmune/Paraneoplastic Evaluation, Spinal Fluid
  
12687
  
LAB12687
  
DMC1
  
Cognitive decline
Cognitive impairment
DEMEC
Dipeptidyl aminopeptidase-like protein 6
Leucine-Rich Glioma Inactivated Protein-1 IgG
  
Dementia, Interpretation, CSF
AMPA-R Ab CBA, CSF
Amphiphysin Ab, CSF
Anti-Glial Nuclear Ab, Type 1
Anti-Neuronal Nuclear Ab, Type 1
Anti-Neuronal Nuclear Ab, Type 2 Anti-Neuronal Nuclear Ab, Type 3
CASPR2-IgG CBA, CSF
CRMP-5-IgG, CSF
DPPX Ab IFA, CSF
GABA-B-R Ab CBA, CSF
GAD65 Ab Assay, CSF
GFAP IFA, CSF
IgLON5 IFA, CSF
LGI1-IgG CBA, CSF
mGluR1 Ab IFA, CSF
Neurochondrin IFA, CSF
NIF IFA, CSF
NMDA-R Ab CBA, CSF
Purkinje Cell Cytoplasmc Ab Type T 1
Purkinje Cell Cytoplasmic Ab Type 2

For reflex tests see algorithm listed on Clinical and Interpretive info tab.
  

 

Investigating new onset dementia and cognitive impairment plus 1 or more of the following accompaniments in cerebrospinal fluid specimens:

  • Rapid onset and progression
  • Fluctuating course
  • Psychiatric accompaniments (psychosis, hallucinations)
  • Movement disorder (myoclonus, tremor, dyskinesias)
  • Headache
  • Autoimmune stigmata (personal history or family history or signs of diabetes mellitus,  thyroid disorder, vitiligo, poliosis [premature graying], myasthenia gravis, rheumatoid arthritis, systemic lupus erythematosus)
  • Smoking history (20+ pack years) or other cancer risk factors
  • History of cancer
  • Inflammatory cerebrospinal fluid
  • Neuroimaging findings atypical for degenerative etiology

Specimen

  
Cerebrospinal fluid (CSF)
  

Sterile vial/container

  
4.0 mL
  
2.0 mL
  

Screw-capped polypropylene vial/tube, sterile (Mayo)

  

Refrigerated (preferred) - 28 days

Frozen - 28 days

Ambient - 72 hours

  
  • Gross hemolysis
  • Gross lipemia
  • Gross icterus

Performance

  
Mayo Clinic Laboratories (DMC2): R-MM
  
Varies
  
8 - 12 days
  

Immunofluorescence assay (IFA)

Cell-binding assay (CBA)

Western blot (WB)

Radioimmunoassay (RIA)

Immunoblot (IB)

Clinical and Interpretive info

  

See report

  

Utilization guidelines for neurologic autoimmune panels

Billing

  
86255 x 19
86341

Additional CPT codes (if appropriate):
84182-AGNBC
86256 AGNTC
86255-AINCC
86256-AMPIC
84182-AMIBC
84182-AN1BC
86256 AN1TC
84182-AN2BC
86256 AN2TC
86256 AN3TC
86256 APHTC
86256 CRMTC
84182-CRMWC
86255-DPPCC
86256-DPPTC
86256-GABIC
86255-GFACC
86256-GFATC
86255-IG5CC
86256-IG5TC
86255 NCDCC
86256 NCDTC
86255-GL1CC
86256-GL1TC
86255-NFHCC
86256-NIFTC
86255-NFLCC
86256-NMDIC
86256 PC2TC
84182-PCTBC
86256 PCTTC

Tracking

  
11/18/2014
  
02/01/2024
  
02/14/2023