• IgG labels plasma cells
• IgG stains will show an interstitial dendritic pattern within lymphoid follicles, (this represents extracellular immune complexes which are bound to the surface of specialized follicular dendritic cells)
• IgG will label occasional B cell lymphomas

When ordering as Technical with Intrepretation, both IgG by IHC and IgG4 by IHC must be ordered together

Submit a formalin-fixed, paraffin-embedded tissue

Formalin-fixed, paraffin-embedded (FFPE) tissue block

FFPE tissue section mounted on a charged, unstained slide

Ambient (preferred)

• Unlabeled/mislabeled block
• Insufficient tissue
• Slides broken beyond repair

Immunohistochemical staining and microscopic examination

If requested, an interpretive report will be provided

Specifications:

• This antibody reacts with heavy chains (gamma) of human IgG (Fc-part)
• This antibody labels plasma cells and various lymphocytes

 Staining pattern:

• Cytoplasmic (plasma cells) and cell surface membrane (lymphocytes)

References

1. Taylor CR et al: The demonstration of plasma cells and other immunoglobulin-containing cells in formalin-fixed, paraffin-embedded tissues using peroxidase-labelled antibody. J Clin Pathol 1974; 27:14-20.
2. Taylor CR et al: The immunohistological detection of intracellular immunoglobulin in formalin-paraffin sections from multiple myeloma and related conditions using the immunoperoxidase technique. Clin exp Immunol 1974; 8:417-29.