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Movement Disorder, Autoimmune/Paraneoplastic Evaluation, Serum-14900

Test info

Test name:

Movement Disorder, Autoimmune/Paraneoplastic Evaluation, Serum

Test number:

14900

Excellian order number:

LAB14900

Abbreviation:

MDS2

Alternate names:

Ataxia
Chorea
Dyskinesias
Myoclonus
Parkinsonism
Brainstem encephalitis

Tests included:

Movement Disorder Interp, S
AMPA-R Ab CBA, S
Amphiphysin Ab, S
Anti-Glial Nuclear Ab, Type 1
Anti-Neuronal Nuclear Ab, Type 1
Anti-Neuronal Nuclear Ab, Type 2
Anti-Neuronal Nuclear Ab, Type 3
AP3B2 IFA, S
CASPR2-IgG CBA, S
CRMP-5-IgG Western Blot, S
DPPX Ab IFA, S
GABA-B-R Ab CBA, S
GAD65 Ab Assay, S
GFAP IFA, S
GRAF1 IFA, S
IgLON5 IFA, S
ITPR1 IFA, S
KLHL11 Ab CBA, S
LGI1-IgG CBA, S
mGluR1 Ab IFA, S
Neurochondrin IFA, S
NIF IFA, S
NMDA-R Ab CBA, S
P/Q-Type Calcium Channel Ab
Purkinje Cell Cytoplasmic Ab Type 1
Purkinje Cell Cytoplasmic Ab Type 2
Purkinje Cell Cytoplasmic Ab Type Tr
Septin-5 IFA, S
Septin-7 IFA, S

For reflex tests, see algorithm listed on Clinical and Interpretive info Tab

Useful for:

Evaluating patients with suspected paraneoplastic or other autoimmune movement disorders including patients with ataxia, chorea, dyskinesias, myoclonus, parkinsonism, and stiff-person spectrum in serum specimens

Specimen

Specimen type:

Serum

Collection container:

Gold serum separator (SST) tube x 2

Volume:

4.0 mL

Minimum volume:

3.0 mL

Collection instructions:

Immediately following collection, mix sample thoroughly by gentle inversion, 5 times

Processing instructions:

Allow sample to clot for a minimum of 30 minutes
Spin within two (2) hours of sample collection
Transfer serum to a Screw cap transfer vial/tube (Mayo T914), labelled as serum

Transport container:

Screw cap transfer vial/tube (Mayo T914)

Alternate collection container:

Red serum vial/tube, 5 mL x 2

Red serum vial/tube, 10 mL

Alternate processing instructions:

Allow sample to clot
Spin
Transfer serum to a Screw cap transfer vial/tube (Mayo T914), labelled as serum, within two (2) hours of sample collection

Transport and stability:

Refrigerated (preferred) – 28 days

Ambient – 72 hours

Frozen – 28 days

Specimen retention time:

28 days

Reason for rejection:

Gross hemolysis
Gross lipemia
Gross icterus

Performance

Performing lab:

Mayo Clinic Laboratories (MDS2): R-NX

Days set up:

Mo - Su
Reflex tests: Varies

TAT:

8 - 12 days

Method:

Immunofluorescence Assay (IFA)

Western Blot (WB)

Cell Binding Assay (CBA)

Radioimmunoassay (RIA)

Immunoblot (IB)

Clinical and Interpretive info

Reference ranges:

See report

Clinical information:

Utilization guidelines for neurologic autoimmune panels

Cautions:

A negative antibody test result does not exclude an autoimmune movement disorder.

Corticosteroid treatment prior to the serum collection may cause a false-negative result.

Intravenous immunoglobulin (IVIg) treatment prior to the serum collection may cause a false-positive result.

Billing

CPT codes:

86596
86255 x 25
84182
86341

Additional CPT codes (if appropriate):
86255 ITPCS
86256 ITPTS
86256 K11TS
86255 NCDCS
86256 NCDTS
86255 NFHCS
86255 NFLCS
86256 NIFTS
86256 NMDIS
84182 PC1BS
86256 PC1TS
86256 PC2TS
84182 PCTBS
86256 PCTTS
86255 SP5CS
86256 SP5TS
86255 SP7CS
86256 SP7TS
86255 ITPCS
86256 ITPTS
86256 K11TS
86255 NCDCS
86256 NCDTS
86255 NFHCS
86255 NFLCS
86256 NIFTS
86256 NMDIS
84182 PC1BS
86256 PC1TS
86256 PC2TS
84182 PCTBS
86256 PCTTS
86255 SP5CS
86256 SP5TS
86255 SP7CS
86256 SP7TS

Tracking

Date created:

02/22/2022

Revised date:

05/01/2023

Review date:

05/01/2023