Deletion of 11q22 (ATM) and 17p13.1 (TP53) are recurring abnormalities of Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic lymphoma (SLL). According to current NCCN CLL guidelines, deletions of 11q22 and 17p13.1 are classified as an unfavorable cytogenetic risk factor.

This test can be ordered individually or as part of a CLL Full Panel, CLL Prognostic Panel, or CLL Progressive Panel. See the individual panel tests for more details.

Bone marrow aspirate:

Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube

- or -

1. Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep), no gel
2. Immediately following collection, mix sample thoroughly by gently inverting 8 - 10 times, to prevent clotting

Transfer aspirate from syringe to transport container. 

Submit entire specimen unspun.

Sterile vial/tube

or

Dk green Sodium heparin (Na hep), no gel

Bone Marrow Core:

Submit in sterile tube/cup filled with sterile culture medium, sterile Hanks Balance Salt Solution (HBSS) or sterile saline

or 

Whole blood:

Dk green Sodium heparin (Na hep), no gel

Immediately following collection, mix sample thoroughly by gently inverting 8 - 10, times to prevent clotting.

Submit entire specimen unspun

Sterile tube/cup

or

Dk green Sodium heparin (Na hepl), no gel

AHL Cytogenetics Oncology Request

Ambient

• Improper label (unlabeled or mislabeled)
• Wrong container (anticoagulant or solution)
• Delay in transport
• Improper storage
• Leaking container
• Slides broken beyond repair

Fluorescence in situ hybridization (FISH)

Normal or Abnormal with interpretation.

Medical necessity