Titer
Detection of gastric parietal cell antibodies of the IgG class in human sera
Immediatley following collection, mix sample by gently inverting 5 times
Gold serum separator (SST) tube
Ambient (preferred) - 14 days
Refrigerated - 14 days
Frozen - 14 days
Freeze/thaw cycles - stable x 3
Enzyme-linked immunosorbent assay (ELISA)
Negative: 0.0 - 20.0
Equivocal: 20.1 - 24.9
Positive: > 24.9
Autoantibodies to gastric parietal cells are found in approximately 90% of patients with pernicious anemia and in about 30% of first degree relatives of patients with pernicious anemia. Increased levels of gastric parietal cells have been found in patients with thyroid disease, iron deficiency anemia, alopecia areata, and vitiligo.