ETV6/RUNX1 by FISH-4280J (malignant tissue)
Test info
B-Lymphoblastic Leukemia/lymphoma
B-ALL
B-cell ALL
FISH
Fluorescence In Situ Hybridization
iAMP21 (amplification RUNX1)
TEL/AML
t(12;21)
ETV6/RUNX1 or TEL/AML or t(12;21), or amplification of RUNX1 (iAMP21) rearrangements, are recurring abnormalities in B-cell ALL. According to current NCCN B-ALL guidelines, ETV6/RUNX1 or TEL/AML or t(12;21) abnormalities are classified as a good cytogenetic risk factor, and amplification of RUNX1 (iAMP21) is classified as a poor cytogenetic risk factor.
This test can be ordered individually or as part of the B-cell ALL FISH Panels. See the panel tests for more details.
Specimen
Sterile cup or tube
5ml
Place specimen in a sterile cup/tube with sterile culture medium, sterile Hanks Balance Salt Solution (HBSS) or sterile saline.
Submit entire specimen
Sterile specimen cup/tube
Touch prep slides
AHL Cytogenetics Oncology Request
Ambient
Blocks will be returned post reporting
- Improper label (unlabeled or mislabeled)
- Slides broken beyond repair
- Heavy metal fixatives are unacceptable
Performance
Fluorescence in situ hybridization (FISH)
Clinical and Interpretive info
Normal or Abnormal with interpretation
Billing
88271 x 2
88275
88291