Screening test for open neural tube defects, Down syndrome, and Trisomy 18.

Gold serum separator (SST) tube

• Serum integrated screening requires two specimens; one collected in the first trimester and one in the second trimester. This test number is for the second trimester portion of the test.
• Collect between 15.0 and 21.9 weeks of gestation.

• Immediatley following collection, mix sample by gently inverting 5 times

1. Allow sample to clot for a minimum of 30 minutes
2. Spin within two (2) hours of sample collection

Pour-off/aliquoting is not advised

Gold serum separator (SST) tube

• Patient must have submitted a previous specimen in the first trimester for the Serum Integrated 1 test.
  • Gestational age will be based on information provided with the first trimester specimen.
• Maternal testing clinical information form

Ambient (preferred) - 7 days

Refrigerated - 14 days

Frozen - 14 days

Freeze/thaw cycles - stable x3

• Gross hemolysis
• Gross lipemia

Chemiluminescent immunoassay

A positive result means that diagnostic testing may be offered to the pregnant woman to determine if a neural tube defect or chromosome abnormality is present.

Medical necessity