Prolactin, Pituitary Macroadenoma, Serum-994
This is the correct prolactin test to rule-out hook effect and dilutions.
Macroprolactin is different test.
Test info
rule out hook effect
Prolactin Macroadenoma
Useful for quantifying prolactin in serum specimens where the high-dose hook effect is suspected (e.g., presence of pituitary tumor with symptoms of prolactinoma and lower than expected serum prolactin concentration).
This test order is restricted to endocrinologists.
Specimen
A pituitary adenoma should be identified by imaging studies prior to ordering this tes
(Note: This volume does not allow for repeat testing.)
- Draw between 8 a.m. and 10 a.m. (levels subsequently increase).
- Immediately following collection, mix sample thoroughly by gentle inversion, 5 times
1. Allow sample to clot for a minimum of 30 minutes
2. Spin within two (2) hours of sample collection
Gold serum separator (SST) tube
Immediately following collection, mix sample thoroughly by gentle inverting 8 - 10 times, to prevent clotting
Red:
- Allow sample to clot
- Spin within two (2) hours of sample collection
- Transfer serum to a Screw-cap polypropylene frozen transport vial/tube - 4mL (LabCorp), labelled as serum
Dk green:
- Spin within two (2) hours of sample collection
- Transfer serum to a Screw-cap polypropylene frozen transport vial/tube - 4mL (LabCorp), labelled as plasma
Refrigerate (preferred) - 14 days
Ambient - 7 days
Frozen - 14 days
Freeze/thaw cycles - stable x3
Samples collected in oxalate, EDTA, or citrate plasma
Performance
Electrochemiluminescence immunoassay (ECLIA)
Clinical and Interpretive info
- Male: 4.0−15.2 ng/mL
- Female: 4.8−23.3 ng/mL