• Elevated serum IgG4 levels may be associated with localized or systemic allergic and autoimmune manifestations, such as inflammatory pseudotumor in liver, breast, and lung, sclerosing pancreatitis, and pemphigus vulgaris
• In these disease states, increased numbers of IgG4-positive plasma cells are present in the tissue

When ordering as Technical with Intrepretation, both IgG by IHC and IgG4 by IHC must be ordered together

Submit a formalin-fixed, paraffin-embedded tissue

Formalin-fixed, paraffin-embedded (FFPE) tissue block

FFPE tissue section mounted on a charged, unstained slide

Ambient (preferred)

• Unlabeled/mislabeled block
• Insufficient tissue
• Slides broken beyond repair

Immunohistochemical staining and microscopic examination

If requested, an interpretive report will be provided

Specifications

• Immunoglobulin function as the surface receptors for antigens for B lymphocytes and as the secretory products of plasma cells forming the humoral arm of the immune system.
• IgG represents one of the immunoglobulin heavy chain types
• IgG4 is the least abundant of IgG subclasses, normally comprising 6% of total IgG

 Staining pattern

• Cytoplasmic