• All IHC stains will include a positive control tissue

• HPL is used to identify syncytiotrophoblastic cells of choriocarcinoma
• HPL is positive in placental site trophoblastic tumors (these tumors can also be focally positive for bHCG)
• HPL will also stain placental site nodules
• HPL can identify the implantation site throughout gestation

Submit a formalin-fixed, paraffin-embedded tissue

Formalin-fixed, paraffin-embedded (FFPE) tissue block

FFPE tissue section mounted on a charged, unstained slide

Ambient (preferred)

• Unlabeled/mislabeled block
• Insufficient tissue
• Slides broken beyond repair

Immunohistochemical staining and microscopic examination

If requested, an interpretive report will be provided

Specifications

• Anti - HPL (also known as human chorionic somatomammotropin) identifies intermediate trophoblasts, and syncytiotrophoblasts

Staining pattern

• Cytoplasmic staining

References

1. Kurman RJ et al: Immunocytochemical localization of HPL and chorionic gonadotropin in the normal placenta and trophoblastic tumors, with emphasis on intermediate trophoblast and the placental site trophoblastic tumor. Int J Gynecol Pathol 1984;3:101-121.