Aneuploidy by FISH X/Y/18, 13/21-4280H (blood), 4280A (Amniotic fluid), 4280B (Chorionic villi)

Test info

  
Aneuploidy by FISH X/Y/18, 13/21
  
4280H (blood), 4280A (Amniotic fluid), 4280B (Chorionic villi)
  
LAB4280H - CYTOGENETIC LEUKEMIC BLOOD STUDIES
4280A - CHROMOSOME STUDY - AMNIOTIC FLUID
4280B CHROMOSOME STUDY - CHORIONIC VILLI
  
Perinatal FISH
Trisomy 13, 18 or 21
Sex chromosome aneusomy
Down Syndrome
Edwards Syndrome
Patau Syndrome
Turner Syndrome
Klinefelter Syndrome

Specimen

  

For prenatal specimens, patient should receive genetic counseling prior to ordering.

  
Sodium heparin (Na hep) whole blood
  

Dk green Sodium heparin (Na hep), no gel

   

  
5.0 mL
  
2.0 mL
  

Immediately following collection, mix sample by inverting 8 - 10 times to prevent clotting.

  

This interphase FISH test MUST be ordered with a chromosome study or chromosomal microarray (CMA) analysis.

 

 

  

 

 

  
Amniotic fluid
Chorionic villi
  

Amniotic fluid: discard the first 2 mL collected.

  
Amniotic fluid: 20 mL
Chorionic villi: 30 mg (minimum 10 mg)
  

Amniotic Fluid:

Falcon vial/tube - 15mL

Chorionic villi: 

Sterile container filled with CVS Collection Media, sterile Hanks Balance Salt Solution or Sterile Saline

  

Ambient

  
  • Improper label (unlabeled or mislabeled)
  • Wrong container (anticoagulant or solution)
  • Improper blood/anticoagulant ratio
  • Delay in transport
  • Improper storage
  • Leaking container

Performance

  
AHL - Cytogenetics: X
  
2 - 3 times per week
  
1 - 3 days for STAT analysis
  

Fluorescence in situ Hybridization (FISH)

Clinical and Interpretive info

  

Normal or abnormal with interpretation.

Note: The Cytogenetics lab does not report mosaic FISH results.

Billing

  
88271 x 5
88274 x 2
  
Yes
  

Medical necessity

Tracking

  
02/16/2011
  
06/15/2015