Test name:  

Myelopathy, Autoimmune/Paraneoplastic Evaluation, Serum

Test number:  

994

Excellian order number:  

LAB994

Abbreviation:  

MSO

Alternate names:  

Paraneoplastic myelopathy
Neuromyelitis optica
Anti-MOG
Anti-GFAP

Useful for:  

Evaluating patients with suspected autoimmune myelopathy, myelitis, and paraneoplastic myelopathy using serum specimens

Patient preparation information:  

• For optimal antibody detection, specimen collection is recommended prior to initiation of immunosuppressant medication or intravenous immunoglobulin treatment.
• This test should not be requested for patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. The specific waiting period before specimen collection will depend on the isotope administered, the dose given, and the clearance rate in the individual patient. Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received in the laboratory will be held 1 week and assayed if sufficiently decayed or canceled if radioactivity remains.

Specimen type:  

Serum

Collection container:  

Red serum vial/tube, 10 mL

Volume:  

4 mL

Minimum volume:  

2 mL

Processing instructions:  

1. Allow sample to clot
2. Spin within two (2) hours of sample collection
3. Transfer serum to a Screw cap transfer vial/tube (Mayo T914), labelled as serum

Transport container:  

Screw cap transfer vial/tube (Mayo T914)

Alternate collection container:  

Gold serum separator (SST) tube

Alternate processing instructions:  

1. Allow sample to clot for a minimum of 30 minutes
2. Spin within two (2) hours of sample collection

Transport and stability:  

Refrigerated (preferred) - 28 days

Frozen - 28 days

Ambeint - 72 hours

Reason for rejection:  

• Gross hemolysis
• Gross lipema
• Gross iicterus

Performing lab:  

Mayo Clinic Laboratories (MAS1); R-NX

TAT:  

8 - 12 days

Reference ranges:  

See report

Clinical information:  

Autoimmune/Paraneoplastic Myelopathy Evaluation Algorithm-Serum

CPT codes:  

86255 x 15
86053
84182
86363
86341
84182 AGNBS (if appropriate)
86256 AGNTS (if appropriate)
86255 AINCS (if appropriate)
84182 AMIBS (if appropriate)
84182 AN1BS (if appropriate)
86256 AN1TS (if appropriate)
84182 AN2BS (if appropriate)
86256 AN2TS (if appropriate)
86256 AN3TS (if appropriate)
86255 APBCS (if appropriate)
86256 APBTS (if appropriate)
86256 APHTS (if appropriate)
86256 CRMTS (if appropriate)
86255 DPPCS (if appropriate)
86256 DPPTS (if appropriate)
86256 GABIS (if appropriate)
86255 GFACS (if appropriate)
86256 GFATS (if appropriate)
86255 GL1CS (if appropriate)
86256 GL1TS (if appropriate)
86363 MOGTS (if appropriate)
86255 NCDCS (if appropriate)
86256 NCDTS (if appropriate)
86255 NFHCS (if appropriate)
86255 NFLCS (if appropriate)
86256 NIFTS (if appropriate)
86053 NMOTS (if appropriate)
84182 PC1BS (if appropriate)
86256 PC1TS (if appropriate)
86256 PC2TS (if appropriate)
86255 SP7CS (if appropriate)
86256 SP7TS (if appropriate)

Date created:  

04/12/2024

Review date:  

04/12/2024