Rearrangements of MAF/IGH are recurring abnormalities in plasma cell dyscrasia disorders including Plasma Cell Myeloma. According to current mSMART 3.0 myeloma guidelines, rearrangement of MAF/IGH is classified as a high-risk cytogenetics category. 

This test can be ordered individually or as part of a Plasma Cell Dyscrasia FISH Panel. See the individual panel test for more details.

Bone marrow aspirate:

Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube

- or -

1. Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep), no gel
2. Immediately following collection, mix sample thoroughly by gently inverting 8 - 10 times, to prevent clotting

Transfer aspirate from syringe to transport container. 

Submit entire specimen unspun.  Specimen will be CD138 enriched for plasma cell isolation.

Sterile container

or

Dk green Sodium heparin (Na hep), no gel

Bone Marrow core:

Submit in sterile tube/cup filled with sterile culture medium, sterile Hanks Balance Salt Solution (HBSS) or sterile saline

or 

Whole blood:

Dk green Sodium heparin (Na hep), no gel

Immediately following collection, mix sample thoroughly by gently inverting 8 - 10, times to prevent clotting.

Submit entire specimen unspun

Sterile tube/cup

or

Dk green Sodium heparin (Na hepl), no gel

AHL Cytogenetics Oncology Request

Ambient

• Improper label (unlabeled or mislabeled)
• Wrong container (anticoagulant or solution)
• Delay in transport
• Improper storage
• Leaking container
• Slides broken beyond repair

Fluorescence in situ hybridization (FISH)

Normal or Abnormal with interpretation

Medical necessity