• All IHC stains will include a positive control tissue

• The primary use for this antibody is in distinguishing between epithelial versus mesothelial proliferations. It is one of the best markers currently available in recognizing adenocarcinoma
• This antibody should be used in a panel (see mesothelioma vs. adenocarcinoma panel)

Submit a formalin-fixed, paraffin embedded tissue block

Formalin-fixed, paraffin embedded (FFPE) tissue block

FFPE tissue section mounted on a charged, unstained slide

Ambient (preferred)

• Unlabeled/mislabeled block
• Insufficient tissue
• Slides broken beyond repair

Immunohistochemical staining and microscopic examination

If requested, an interpretive report will be provided

Specifications

• MOC-31 is an antibody directed against a small cell carcinoma cell line
• It reacts with an epithelial antigen present on most normal and malignant epithelia
• Reactive mesothelial cells and malignant mesotheliomas show rare expression with this antibody

Staining pattern

• Membrane based staining

References

1. Sosolik RC, et al. Anti-MOC-31: a potential addition to the pulmonary adenocarcinoma versus mesothelioma immunohistochemistry panel. Mod Pathol 1997; 10:716-719.
2. Ordonez NG. The immunohistochemical diagnosis of epithelial mesothelioma. Hum Pathol 1999; 30:313-23.
3. Ruitenbeek T, et al. Immunocytology of body cavity fluids. MOC031, a monoclonal antibody discriminating between mesothelial and epithelial cells. Arch Pathol Lab Med 1994; 118:265.