All special stains will include a positive control tissue

This procedure is used for the demonstration of nerve fibers and the presence of neurofibrillary tangles and senile plaques in Alzheimer disease. 

As aging occurs, most individuals develop alteration of neurofibrils in at least some neurons; the neurofibrils may become clumped or twisted.  In Alzheimer disease, tremendous numbers of the neurofibrillary tangles develop.

Formalin vial/container

Prepare a formalin-fixed, paraffin-embedded (FFPE) tissue block

FFPE tissue block

Prepare two (2) 8 micron thick section unstained positively charged slides from an FFPE tissue block

Slides in a Slide holder - 5 specimen

Histopathology Processing & Special Stains requisition

Ambient

Protect paraffin block and/or slides from excessive heat

• Insufficient tissue in block
• Mislabeled/Unlabeled block or slides
• Broken slides

Histochemical staining and microscopic evaluation

An interpretive pathology report will be provided for Technical with Interpretation cases.