• All IHC stains will include a positive control tissue

The primary use for this antibody is in identifying the calcitonin production in thyroid (c-cell hyperplasia and medullary carcinoma) as well by other tumors

Submit a formalin-fixed, paraffin embedded tissue block

Formalin-fixed, paraffin embedded (FFPE) tissue block

FFPE tissue section mounted on a charged, unstained slide

Ambient (preferred)

• Unlabeled/mislabeled block
• Insufficient tissue
• Slides broken beyond repair

Immunohistochemical staining and microscopic examination

If requested, an interpretive report will be provided

Specifications

• Calcitonin secretion occurs in normal and neoplastic thyroid, and results in hypocalcemic actions on bone and kidney
• Calcitonin secretion is usually associated with medullary carcinoma of the thyroid, as well as in C-cell hyperplasia
• The identification of calcitonin production in c-cell hyperplasia is useful in recognizing familial forms of this disease
• Calcitonin secretion has also been demonstrated in thymic carcinoids, as well as in breast and lung cancers (such as small cell carcinomas)

 Staining patterns

• Cytoplasmic based granular activity

References:

1. Melvin KEWQ et al, N Eng J Med 285:1115-1120, 1970.
2. DeLellis RA et al, Am J Pathol 72:119-128, 1973