Hemoglobin (Hb) solubility-13333
Test info
Hemoglobin (Hb) solubility
13333
LAB13333
HSS
Hb S
Hemoglobin S
Hgb solubility
Sickle cell preparation
Sickle cell solubility test
Sickle cell test
Sickle prep
Sickledex
Hemoglobin S
Hgb solubility
Sickle cell preparation
Sickle cell solubility test
Sickle cell test
Sickle prep
Sickledex
- Qualitative determination of presence of hemoglobin S
- Detect sickling hemoglobins
- Evaluate hemolytic anemia, undiagnosed hereditary anemia with morphologic (sickle-like) abnormalities on peripheral blood smear
Specimen
EDTA whole blood
1.0 mL
0.1 mL
Immediately following collection, mix sample thoroughly by gentle inverting 8 - 10 times, to prevent clotting
Lavender (EDTA), 4mL
Sodium citrate (Na cit) whole blood
ACD whole blood
Heparin whole blood
ACD whole blood
Heparin whole blood
Lt blue Sodium citrate (NaCit)
Yellow ACD (A or B)
Dk green heparin (Li or Na), no gel
Ambient (preferred) - 14 days
Refrigerated - 14 days
Frozen - 14 days
Freeze/thaw cycles - stable x 3
- Specimen other than whole blood received
- Clotted specimen
Performance
LabCorp Burlington (005223): R-LC
Mo - Fr
1 - 3 days
Sodium hydrosulfite reduction
Clinical and Interpretive info
Negative
Distinction between Hb S beta-thalassemia and sickle cell anemia is not always possible on clinical, hematologic, or electrophoretic grounds. Thalassemia heterozygotes have hypochromia and microcytosis, but overlap values exist. Differentiation can best be made by family or molecular pathology methods. Regional prevalence in the midwest area of Hb S beta-thalassemia is estimated to be 1:23,000 of the black population. It is recommended that positive sickle cell patients be further evaluated with Hb fractionation (HPLC), Hb F studies, and family studies. Complete characterization may require sophisticated laboratory studies with DNA amplification.
Billing
85660
Tracking
04/05/2019
11/11/2019
12/26/2023