C-telopeptide-14230
Test info
Beta Crosslaps
Carboxyterminal Cross-linking Telopeptide of Bone Collagen
Collagen Cross-linked C-Telopeptide
Crosslaps
CTX
Type 1 Collagen
For in vitro diagnostic use as an indicator of human bone resorption. This test may be used as an aid in monitoring bone resorption changes of antiresorptive therapies in postmenopausal women, individuals with osteopenia, and in predicting skeletal response (bone mineral density) in postmenopausal women undergoing antiresorptive therapies.
- Hormone replacement therapies (HRT) with hormones and hormone-like drugs
- Bisphosphonate therapies
Specimen
Biotin, commonly found in hair, skin and nail supplements and multivitamins, may interfere with assay. Patients should be cautioned to stop biotin consumption at least 72 hours prior to sample collection.
Immediately following collection, thoroughly mix sample by gently inverting 5 times
- Allow sample to clot for a minimum of 30 minutes
- Spin within 45 minutes of sample collection
- Transfer serum to a Screw-cap polypropylene frozen transport vial/tube - 4mL (LabCorp), labelled as serum
- Freeze
Frozen (preferred) - 3 months
Freeze/thaw cycles - stable x6
Refrigerated - 2 days
Ambient - 6 hours
Performance
Electrochemiluminescence immunoassay (ECLIA)
Clinical and Interpretive info
Male: 38 - 724 pg/mL
Female:
Premenopausal: 34 - 635 pg/mL
Postmenopausal: 34 - 1037 pg/mL