• All IHC stains will include a positive control tissue

• May be useful in a panel for neuroendocrine tumors
• Other more specific neuroendocrine markers include chromogranin, Synaptophysin, and Leu-7
• Infrequent positive staining in many non-neuroendocrine tumors has been identified with NSE due to cross-reactivity

Submit a formalin-fixed, paraffin embedded tissue block

Formalin-fixed, paraffin embedded (FFPE) tissue block

FFPE tissue section mounted on a charged, unstained slide

Ambient (preferred)

• Unlabeled/mislabeled block
• Insufficient tissue
• Slides broken beyond repair

Immunohistochemical staining and microscopic examination

If requested, an interpretive report will be provided

Specifications

• NSE is an isoenzyme of the glycolytic enzyme enolase that is expressed primarily in neurons and neuroendocrine tissues
• NSE is also expressed in platelets, T-lymphocytes, megakaryocytes, striated and smooth muscle cells

Staining pattern

• Diffuse cytoplasmic