Eculizumab monitoring panel, serum-994

Test info

  
Eculizumab monitoring panel, serum
  
994
  
LAB994
  
MSO
  
ECULI
ECUMP
Soliris
Alexion
  
Eculizumab
Eculizumab Complement Blockage} Eculizumab Interpretation
  

Therapeutic drug monitoring of Eculizumab

Specimen

  
  • Fasting specimens are preferred

Fasting for a blood test

  • Suggest discontinuing natalizumab at least 4 weeks prior to testing for eculizumab quantitation in serum
  
Serum
  
  
2.0 mL
  
1.0 mL
  
  • Recommended timeframe for the blood collection is a trough, or immediately prior to next scheduled dose
  • Immediately after specimen collection, place the tube on wet ice.\
  
  1. Allow specimen to clot while on wet ice
  2. Spin
  3. Transfer serum to two (2) Screw cap transfer vial/tube (Mayo T465)
  4. Freeze specimen within 30 minutes.
  
  

Frozen (strict) - 14 days

Refrigerated - NO

Ambient - NO

  
14 days
  
  • Gross hemolysis or lipemia
  • Serum gel (SST) tubes

Performance

  
Mayo Clinic Laboratories (ECMP) via LabCorp (009985) : R-NX
  
Varies
  
3 - 10 days
  
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
  • High Resolution Accurate Mass

Clinical and Interpretive info

  

Eculizumab Complement Blockage:

> or =46% normal

Eculizumab:

Lower limit of quantitation =5.0 mcg/mL

>35 Therapeutic concentration for paroxysmal nocturnal hemoglobinuria (PNH)

>50 Therapeutic concentration for atypical hemolytic uremic syndrome (aHUS)

Billing

  
80299
86161

Tracking

  
06/20/2022
  
12/08/2023
  
12/08/2023