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Eculizumab monitoring panel, serum-994

Test info

Test name:

Eculizumab monitoring panel, serum

Test number:

994

Excellian order number:

LAB994

Abbreviation:

MSO

Alternate names:

ECULI
ECUMP
Soliris
Alexion

Tests included:

Eculizumab
Eculizumab Complement Blockage} Eculizumab Interpretation

Useful for:

Therapeutic drug monitoring of Eculizumab

Specimen

Patient preparation information:

Fasting specimens are preferred

Fasting for a blood test

Suggest discontinuing natalizumab at least 4 weeks prior to testing for eculizumab quantitation in serum

Specimen type:

Serum

Collection container:

Red serum vial/tube, 5 mL

Volume:

2.0 mL

Minimum volume:

1.0 mL

Collection instructions:

Recommended timeframe for the blood collection is a trough, or immediately prior to next scheduled dose
Immediately after specimen collection, place the tube on wet ice.\

Processing instructions:

Allow specimen to clot while on wet ice
Spin
Transfer serum to two (2) Screw cap transfer vial/tube (Mayo T465)
Freeze specimen within 30 minutes.

Transport container:

Screw cap transfer vial/tube (Mayo T465) x2

Transport and stability:

Frozen (strict) - 14 days

Refrigerated - NO

Ambient - NO

Specimen retention time:

14 days

Reason for rejection:

Gross hemolysis or lipemia
Serum gel (SST) tubes

Performance

Performing lab:

Mayo Clinic Laboratories (ECMP) via LabCorp (009985) : R-NX

Days set up:

Varies

TAT:

3 - 10 days

Method:

Enzyme-Linked Immunosorbent Assay (ELISA)
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
High Resolution Accurate Mass

Clinical and Interpretive info

Reference ranges:

Eculizumab Complement Blockage:

> or =46% normal

Eculizumab:

Lower limit of quantitation =5.0 mcg/mL

>35 Therapeutic concentration for paroxysmal nocturnal hemoglobinuria (PNH)

>50 Therapeutic concentration for atypical hemolytic uremic syndrome (aHUS)

Billing

CPT codes:

80299
86161

Tracking

Date created:

06/20/2022

Revised date:

12/08/2023

Review date:

12/08/2023