Therapeutic drug management
Trough levels are most reproducible
Dk green heparin (Li or Na), no gel
Immediately following collection, mix sample thoroughly by gently inverting 8 - 10 times, to prevent clotting
Transfer vial/tube with cap - 12mL (LabCorp)
Refrigerated (preferred)
Ambient - <3 days
Frozen (OK)
Gel-barrier tubes are not recommended
High-pressure liquid chromatography with ultraviolet detection (HPLC/UV)
The effective concentration range of isoniazid is dependent on the minimum inhibitory concentration of the pathogen being treated.
Toxic range: >20 µg/mL