Test name:  

Inheritest High Frequency Panel

Test number:  

15265

Excellian order number:  

LAB15265

Abbreviation:  

INH-HF

Alternate names:  

Ashkenazi Jewish
Expanded carrier testing
Pan-ethnic carrier screening

Tests included:  

alpha-thalassemia (HBA1, HBA2)
Bardet-Biedl syndrome (BSS1, BSS2)
Beta-hemoglobinopathies
Sickle cell disease
beta-thalassemias (HBB)
Bloom syndrome (BLM)
Canavan disease (ASPA)
Carnitine palmitoyltransferase II deficiency (CPT2)
cystic fibrosis (CTFR)
Dihydrolipoamide dehydrogenase deficiency (DLD)
Ehlers-Danlos-like syndrome (TXNB)
Familial dysautonomia (ELP1)
Familial hyperinsulinism (ABCCB)
Fanconi anemia (FANCC)
Fragile X syndrome (FMR1)
Galactosemia (GALT)
Gaucher disease (GMA)
Glycogen storage disease type 1 (G6PC1), SCL37A4)
Joubert syndrome
Meckel-Gruber syndrome (AHI1, CC2DA, TME216)
Maple syrup urine disease (MSUD)
Metachromatic leukodystrophy (ARSA)
Mucolipidosis type IV (MCOLN1)
Nemaline myopathy (NEB)
Niemann-Pick disease types A and B (SMPD1)
Phenylalanine hydroxylase deficiency
Phenylketonuria (PKU PAH)
Polycystic kidney disease, autosomal recessive (PKHD1)
Retinitis pigmentosa (DHDDS, RPGR)
Smith-Lemli-Opitz syndrome (DHCR7)
Spinal muscular atrophy (SMN1)
Tay-Sachs disease (HEXA)
Tyrosinemia type I (FAH)
Usher syndrome (hearing loss an dretinitis pigmentosa) (CLRN1, PCDH15, USH2A)
Walker-Warburg syndrome and other FKTN related dystrophies (FKTN)
Wilson disease (ATP7B)

Useful for:  

This test is used for pan-ethnic carrier screening and includes 110 of the genes included in the American College of Medical Genetics (ACMG) Tier 3 category.

Limitations:  

Males are not tested for x-linked disorders, including fragile X syndrome.

Specimen type:  

ACD whole blood

Collection container:  

Yellow ACD (A or B)

 

Volume:  

8.5 mL

Minimum volume:  

3.0 mL

Collection instructions:  

Immediatley following collection, mix sample by inverting 8 - 10 times to prevent clotting

Processing instructions:  

Do not spin

Transport container:  

Yellow ACD (A or B)

Alternate specimen type:  

EDTA whole blood

Alternate collection container:  

Lavender (EDTA), 4mL x3

Required forms/information:  

Informed consent and patient history form:

Clinical Questionnaire for Inheritest® Carrier Screen and GeneSeq® PLUS

Molecular Medicare billing request

Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medicare billing request form to notify us of the need for Allina Health Laboratory to bill insurance.

 

Transport and stability:  

Ambient (preferred) - 4 days

Refrigerated - 4 days

Frozen - NO

Reason for rejection:  

• Frozen specimen
• Hemolyzed specimen

Performing lab:  

LabCorp (481816) - R-LC

TAT:  

14-21 days

Reference ranges:  

See report

Preauthorization:  

This test may require preauthorization from the insurance provider. Check the payer guidelines and, if needed, obtain the pre-authorization prior to sample collection.

Subject to medical necessity (Y/N):  

Yes

Other billing information:  

Medical necessity

Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medicare billing request form to notify us of the need for Allina Health Laboratory to bill insurance.

Molecular Medicare billing request

Date created:  

08/06/2024

Revised date:  

08/08/2024

Review date:  

08/06/2024