Providing prognostic information in patients with newly diagnosed B-cell chronic lymphocytic leukemia.

Lavender (EDTA), 4mL

Immediately after collection, mix tube thoroughly by gentle inversion, 8 - 10 times, to prevent clotting

Lavender (EDTA), 4mL

Yellow ACD (A or B)

Bone Marrow (in EDTA or ACD):

1. Immediately following collection, mix sample thoroughly by gently inverting 8 - 10 times, to prevent clotting
2. Send specimen in original tube, labelled as bone marrow

Extracted DNA from whole blood or bone marrow:

1. Label specimen as extracted DNA and indicate specimen source (blood or bone marrow).
2. The required volume of DNA is 50 mcL at a concentration of 20 ng/mcL
3. Include volume and concentration on tube.

Bone marrow:

Lavender (EDTA), 4mL

Yellow ACD (A or B)

Extracted DNA:

1.5 to 2mL screw-top tube (extracted DNA)

B-Cell Chronic Lymphocytic Leukemia (CLL) for IGVH and/or TP53 Somatic Mutation Testing form

Molecular Medicare Billing Request

Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medicare billing request form to notify us of the need for Allina Health Laboratory to bill insurance.

Whole blood or Bone marrow:

Refrigerated (preferred) - 7 days

Ambient - 7 days

Extracted DNA:

Frozen (preferred)

Refrigerated

• Gross hemolysis
• Moderate to severly clotted sample

Polymerase Chain Reaction (PCR) and Next-Generation Sequencing for IGH Somatic Mutation Status in CLL

An interpretive report will be provided

Medical necessity

Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medicare billing request form to notify us of the need for Allina Health Laboratory to bill insurance.

Molecular Medicare Billing Request