Lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia, MYD88 L265P with reflex to CXCR4-994
Test info
L265P
LPL/WM
Lymphoplasmacytic lymphoma
MYD88
CXCR4
Waldenstrom Macroglobulinemia
CXLPL
S338X
If a MYD88 L265P variant is detected, additional CXCR4 testing will be performed.
If a MYD88 L265P variant is not detected, the algorithm ends and no further testing is necessary.
- Establishing the diagnosis of lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia (LPL/WM)
- Helping distinguish LPL/WM low-grade B-cell lymphoma from other subtypes
- Aiding in the prognostication and clinical management of LPL/WM
Specimen
- Invert several times to mix bone marrow
- Label specimen as bone marrow
Send bone marrow specimen in original tube. Do not aliquot.
Lavender (EDTA), 4mL
Yellow top (ACD solution B)
- Invert several times to mix blood
- Label specimen as peripheral blood
Send whole blood specimen in original tube. Do not aliquot.
- Pertinent clinical history
- Clinical or morphologic suspicion
- Date and time of collection
- Specimen source
Molecular Medicare Billing Request
Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medicare billing request form to notify us of the need for Allina Health Laboratory to bill insurance.
Ambient (preferred) - 10 days
Refrigerate - OK
- Gross hemolysis
- Clotted
Performance
Allele-Specific Polymerase Chain Reaction (AS-PCR), Bridged Nucleic Acids (BNA) Clamp Sanger Sequencing and routine Sanger Sequencing
Clinical and Interpretive info
Reportable variant present or not detected.
An interpretive report will be provided.
Billing
Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medicare billing request form to notify us of the need for Allina Health Laboratory to bill insurance.