All IHC stains will include a positive control tissue

• CD7 is used in the evaluation of T-cell malignancies. It is the most frequently lost pan T cell marker in T-cell lymphomas
• CD7 must be used in a panel with other T-cell markers

Submit a formalin-fixed, paraffin-embedded tissue

Formalin-fixed, paraffin-embedded (FFPE) tissue block

FFPE tissue section mounted on a charged, unstained slide

Ambient (preferred)

• Unlabeled/mislabeled block
• Insufficient tissue
• Slides broken beyond repair

Immunohistochemical staining and microscopic examination

If requested, an interpretive report will be provided

Specifications

• CD7 antibody is a pan T-cell marker that recognizes a human T cell and NK cell 40KD glycoprotein
• CD7 antigen is an early expressed marker that persists throughout T cell differentiation
• CD7 is found on the majority of peripheral T lymphocytes, most NK cells, and on thymocytes
• CD7 expression can also be found in acute myeloid leukemias

Staining pattern

• Cell surface membrane staining

References

1. Reinhold U, et al: CD7 T-cells represent a subset of normal human blood lymphocytes. J Immunol 150(5);: 2081-2089, 1993.
2. Picker LJ, et al: Immunophenotypic criteria for the diagnosis of non-Hodgkin's lymphoma. Am J Pathol 1987; 128:181-201.